02753nam a2200397Ia 4500 3228 20260820085646.0 210817s9999 xx 000 0 und d 9780132 064521 Hardcover. RDA ENGLISH 3228 540 PETR Petrucci, ralph H. Toronto, Ont., [c.2011] 10th ed 2011. Author. 178758 Bible Society of South Africa General chemistry: principles and modern applications Ralph H. Petrucci [and others]. 10th ed. Toronto, Ont.: Pearson Canada, 2011. xxiv, 1303 pages Colour illustrations: 28 cm Includes index. The Molecule on the Front Cover is Paclitaxel, C47H51NO14 a chemotherapy drug that has been successful in treating breast, lung, and ovatian cancer. It is extracted from the bark of the Pacific Yew tree (Taxus brevifolia). Unfortunately, the bark of a 100-year-old Pacific Yew tree yields about 3 kg of bark and only 300 mg of paclitaxel, barely enough for a single dose of the drug (Taxol).The synthesis of this molecule engaged the attention of chemists for more than 20 years until finally, in 1994, chemists from Florida State University and from the University of California (San Diego) announced independently that they were able to synthesize it from simpler and readily available starting materials. A major challenge in the synthesis of paclitaxel is getting the spatial arrangement of atoms around 11 of the carbon atoms just right. These 11 carbon atoms are identified in the ball-and-stick structure by green or purple circles. If the synthesis is not done carefully, up to 2048 different possible paclitaxel-like structures could be obtained, but only one is known to have the desired anti-tumor activity. Because chemists can now synthesize paclitaxel, it is possible for researchers to explore how it works and design new chemotherapeutic drugs that are safer and more effective. --Book Jacket. Adult. 8190 Petrucci, Ralph H. Toronto, Ont., [c.2011] 10th ed 2011. Author. 176682 Pearson 178919 Critical world issues 197108 Natural Science 196576 South Africa 181703 Problems and exercises 181968 Adult Non-Fiction 176459 Earth sciences 186049 United States 186867 Chemistry 8190 Petrucci, Ralph H. Toronto, Ont., [c.2011] 10th ed 2011. Author. 187737 HERRING F GEOFFREY 2011. Author. 176682 Pearson 178758 Bible Society of South Africa BOOK ddc 559 Nosiswe Mogale 118628 118626 0 0 0 0 2021-08-17 313.00 0 3228200016218 2021-08-17 2021-08-17 BK 0 0 ddc 0 0 500 MKHUL MKHUL Non_Fiction 2026-08-20 0 540 PETR 3228 02060492 0 2026-08-20 2026-08-20 BOOK