000			02753nam a2200397Ia 4500
003			3228
005			20260820085646.0
008			210817s9999 xx 000 0 und d
020			_a9780132 064521 _qHardcover.
040			_aRDA _bENGLISH _c3228
082			_a540 PETR
100			_a Petrucci, ralph H. Toronto, Ont., [c.2011] 10th ed _d2011. _eAuthor.
111			_9178758 _aBible Society of South Africa
245		0	_aGeneral chemistry: _bprinciples and modern applications _c Ralph H. Petrucci [and others].
250			_a10th ed.
260			_aToronto, Ont.: _bPearson Canada, _c2011.
300			_a xxiv, 1303 pages _bColour illustrations: _c28 cm
504			_aIncludes index.
520			_aThe Molecule on the Front Cover is Paclitaxel, C47H51NO14 a chemotherapy drug that has been successful in treating breast, lung, and ovatian cancer. It is extracted from the bark of the Pacific Yew tree (Taxus brevifolia). Unfortunately, the bark of a 100-year-old Pacific Yew tree yields about 3 kg of bark and only 300 mg of paclitaxel, barely enough for a single dose of the drug (Taxol).The synthesis of this molecule engaged the attention of chemists for more than 20 years until finally, in 1994, chemists from Florida State University and from the University of California (San Diego) announced independently that they were able to synthesize it from simpler and readily available starting materials. A major challenge in the synthesis of paclitaxel is getting the spatial arrangement of atoms around 11 of the carbon atoms just right. These 11 carbon atoms are identified in the ball-and-stick structure by green or purple circles. If the synthesis is not done carefully, up to 2048 different possible paclitaxel-like structures could be obtained, but only one is known to have the desired anti-tumor activity. Because chemists can now synthesize paclitaxel, it is possible for researchers to explore how it works and design new chemotherapeutic drugs that are safer and more effective. --Book Jacket.
521			_aAdult.
600		0	_98190 _a Petrucci, Ralph H. Toronto, Ont., [c.2011] 10th ed _d2011. _qAuthor.
610		0	_9176682 _aPearson
630		0	_9178919 _aCritical world issues
650		0	_9197108 _aNatural Science
651		0	_9196576 _aSouth Africa
654			_9181703 _aProblems and exercises
655		0	_9181968 _aAdult Non-Fiction
658			_9176459 _aEarth sciences
662			_9186049 _aUnited States
690			_9186867 _aChemistry
700			_98190 _a Petrucci, Ralph H. Toronto, Ont., [c.2011] 10th ed _d2011. _eAuthor.
700			_9187737 _aHERRING F GEOFFREY _d2011. _eAuthor.
710			_9176682 _aPearson
711			_9178758 _aBible Society of South Africa
942			_cBOOK _2ddc _y559 _zNosiswe Mogale
999			_c118628 _d118626